Wentworth-Douglass Hospital was not spared from layoffs by Mass General Brigham as it cited an anticipated "budget gap" of $250 million.

Mass General Brigham attributed the layoffs to an expected budget shortfall of $250 billion over the next two years.

BOSTON - Mass General Brigham, the largest health care system in Massachusetts, announced layoffs Monday that will affect hundreds of workers, citing a $250 million projected budget gap.

Facing rising costs and hoping to make its sprawling network more efficient, the state’s largest private employer aims to cut payroll costs by over $200 million.

At least three high-level employees at Nantucket Cottage Hospital left abruptly recently, after the parent company of the island's only hospital announced layoffs last week.

Mass General Brigham announced layoffs for hundreds of administrative and management employees on Monday in anticipation of a $250 million budget gap, an unprecedented decision for Massachusetts’ largest private employer.

The layoffs could potentially impact employees at 12 hospitals under the MGB umbrella: While executives say the sweeping cuts are aimed at management and administrative-level employees with no impact on front-line workers, Boston University School of Public Health’s David Rosenbloom suspects the changes could reach patients.

Mass General Brigham announced mass layoffs aimed to bridge a $250 million budget gap projected over the next two years in a letter to employees Monday -- meaning potentially hundreds of firings may be quickly coming down the line.

Nonprofit giant Mass General Brigham will be laying off numerous nonclinical employees to close major budget shortfalls. | The major nonprofit system declined to put a number on the cuts and consolidations,

Mass. General Brigham is planning to lay off hundreds of employees over the next two months as part of a broader restructuring effort to address a significant budget deficit.