Arizona’s 24-23 win on Oct. 6 of last season, a game in which the 49ers led 23-10, helped chart the path to a 6-11 season.

San Francisco 49ers kicker Eddy Pineiro (18) kicks the game-winning field goal against the Arizona Cardinals at the end of the fourth quarter at Levi's Stadium in Santa Clara, Calif., on Sunday, Sept. 21, 2025. (Nhat V. Meyer/Bay Area News Group)

The Niners are without their starting quarterback, Brock Purdy, and have Mac Jones at the helm. He struggled with turning the ball over between his time with the New England Patriots and Jacksonville Jaguars, but put up 279 yards, three touchdowns and no picks last week.

The 49ers (3-0) won their home opener 16-15 on Eddy Pineiro’s walk-off field goal against the Arizona Cardinals.

The NFC West didn't change at all in terms of standings in Week 6. The Seattle Seahawks and Los Angeles Rams won, while the San Francisco 49ers and Arizona Cardinals lost, but the standings remained the same.

Brock Purdy has been out of action for the San Francisco 49ers with a turf toe injury, but the quarterback will eventually return to the lineup when he is healthy.

The San Francisco 49ers have activated star tight end George Kittle from injured reserve. Kittle missed the past five games with a hamstring injury.

When the 49ers hired Robert Saleh to be their defensive coordinator this offseason, they knew they probably wouldn't have him for long.

The 49ers are hoping to overcome their barrage of injuries, while the Falcons are seeking their third straight win. Follow our writers for news, updates and analysis on their respective teams. Time: 8:20 p.