Deoxyribonucleic acid (DNA) replication is fundamental to life, yet the precise mechanics of how helicases unwind the genome for replication remain unclear. A recent study published in Nature used ...
The adenosine triphosphate (ATP) analog ATPγS often greatly slows or prevents enzymatic ATP hydrolysis. The eukaryotic CMG (Cdc45, Mcm2 to 7, GINS) replicative helicase is presumed unable to hydrolyze ...
BUFFALO, N.Y. – New research reveals that triggering a cell’s DNA damage response could be a promising avenue for developing novel treatments against several rare but devastating viruses for which no ...
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