Instead, CICR acts as a dormant but dangerous silent risk factor, staying quiet under normal conditions yet becoming a major driver of pathology when RyR1 signaling is disrupted. This model resolves a ...
Researchers engineered mice with a mutation (E3896A) in the RyR1 calcium-binding site, eliminating calcium-induced calcium release (CICR) without affecting depolarization-induced calcium release. The ...
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