Justin Chambers' Grey's Anatomy exit prompted an unexpected departure for Alex Karev, whose exit storyline continues to be ...

"Nothing's as bad as broccoli." That's what longtime Grey's Anatomy doctor Alex Karev (Justin Chambers) kept reminding a young patient on Thursday's episode, but in reality, his crisis was far worse.

'Grey's Anatomy' turns 21 this year. As you reminisce about this incredible show, see how the cast has changed over its 16-year run!

The idea of "Grey's Anatomy" airing without ever including Dr. Alex Karev, played by Justin Chambers, feels unthinkable and totally foreign at this point, 21 years into its legendary primetime run.

We’ve already covered the demise of one Grey’s Anatomy love triangle. Now it looks like another is set to bite the dust.

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