By degrading PNNs using the enzyme Chondroitinase ABC, the researchers were able to observe how damage to these structures impacted synapses and astrocytes, Interestingly, they found that synapses ...

Alterations in cortical parvalbumin (PV)-containing neurons, including a reduced density of detectable neurons and lower PV levels, have frequently been reported in the dorsolateral prefrontal cortex ...

Kristian Lensjø has taken a PhD at the University of Oslo investigating the mechanisms of learning and memory. His work has contributed to the understanding of perineuronal nets. The brain must ...

Specialized aggregations of extracellular matrix called perineuronal nets (PNNs) appear during juvenile stages of development and surround primarily fast-spiking, parvalbumin (PV)-containing GABAergic ...

Perineuronal nets, rigid structures that hold certain neurons in place, affect a surprising amount of brain activity, including some associated with chronic pain. Neuroscientists, being interested in ...

The latticework of extracellular protein that surrounds brain cells forms a particularly dense mesh around fast-spiking interneurons. Why do these cells need such thick coats? In the July 17 Nature ...

In normal mice, neurons in the deep cerebellar nuclei are surrounded by PNNs and show robust neuronal activity during social interaction, allowing normal transmission of signals through ...