Inside every human cell, proteins are constantly being tagged with small chemical modifications after they're produced. Known ...
Post-translational modifications (PTMs) play a key role in dynamic cellular processes, regulating gene expression, protein activity, localization, and degradation, as well as protein interaction.
Objectives Smoking is recognised as one of the strongest environmental risk factors for the development of rheumatoid ...
The focus of vertebrate studies has mainly been on canonical phosphorylation, but research indicates that phosphorylation of other non-canonical amino acids also regulates integral aspects of cell ...
Post-translational modifications (PTMs)—the chemical changes that proteins undergo following biosynthesis—account for most protein forms, or proteoforms. Indeed, according to conservative estimates, ...
Lactylation, a recently identified post-translational modification, has emerged as important for immune regulation, tissue repair, cancer cell metabolism, and now, potentially, Alzheimer’s disease. In ...
Being bullied leaves a biochemical footprint in the brain. Protein lactylation is a very recently discovered post-translational modification of protein that involves the addition of a lactyl group to ...
As the “Method of the Year 2024”, spatial proteomics (SP) enables in situ characterization of protein localization, abundance, and interactions across subcellular to tissue scales, surpassing ...
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