A new study published in Nature Structural & Molecular Biology reveals how the fundamental enzyme called DNA polymerase delta operates during DNA replication, making a copy of the genetic code that ...

It has long been thought that two enzymes, the kinases CDC7 and CDK2, are both needed to trigger DNA replication in mammalian cells. This view is challenged by evidence that offers a revised view of ...

Sometimes a replicating cell must choose the lesser of two evils. For example, when a replicating cell is stressed, it may struggle to pair bases against its single-stranded DNA (ssDNA) template, even ...

Enzymes, which are crucial to controlling how cells replicate in the human body, could be the very ingredient that encourages DNA to spontaneously mutate -- causing potentially permanent genetic ...

For all species, the process of DNA replication requires the use of multiple different DNA polymerase enzymes. The primary function of these unique multisubunit enzymes is to ensure optimal DNA ...

Researchers at the University of California, Davis, have just reported a small but significant accomplishment: catching the replication of a single DNA molecule on video for the first time. And the ...

During cell growth, cells copy their DNA through a process called DNA replication. For this process to be accurate, the genetic and epigenetic information must be copied flawlessly. In this regard, ...

Studies of recombination-dependent replication (RDR) in the T4 system have revealed the critical roles played by mediator proteins in the timely and productive loading of specific enzymes onto ...

What is DNA, and how does it work? You don't need a degree in genetics to understand. Here, we'll give an overview of DNA and ...

In nature, evolution takes years to sculpt new traits. In the lab, scientists hope to achieve this feat much faster: Being able to evolve proteins with enhanced or novel functions has important ...

A new study shows that the TLK1 and TLK2 enzymes are critical for ensuring the copying of DNA. The research is based on previous studies that pointed to TLK1/2 as potential candidate targets in cancer ...