New research from the Snow Center for Immune Health is challenging long-held assumptions about autoimmune disease, revealing ...

Metabolism guides the activation states of regulatory T cells, the immune cells that prevent inappropriate activation of the immune system. St. Jude Children's Research Hospital scientists recently ...

CD8 + cytotoxic T lymphocytes (CTLs) serve as central effectors in cancer immunotherapy by directly eliminating tumor cells. However, current clinical therapies face significant limitations. These ...

Researchers at Columbia University’s Sadelain lab and University Hospital Tubingen used CRISPR gene editing to knock out the ...

T cells are crucial components of our immune system, serving as critical protectors against infection and disease. But there are limits to their defensive capabilities. T cells are not inexhaustible ...

Researchers screening roughly 400 transcription factors found that disabling a single protein, NFIL3, allowed CAR T-cells to sustain their tumor-killing activity longer in preclinical models. The ...

Immunotherapy has transformed cancer care, offering a way to harness the body’s own immune system to fight tumors. But even with these advances, many patients still don’t respond. One major barrier to ...

Chimeric antigen receptor T cell (CAR-T) therapies have revolutionized treatment for various blood cancers. When traditional treatments fail, CAR-T therapies provide a second highly effective option.

New preclinical and translational findings position DNase I as a potentially transformative adjunct therapy for CAR-T ...

In a new study published in Science titled, “Mitochondrial metabolism and signaling direct dendritic cell function in antitumor immunity,” researchers from St. Jude Children’s Research Hospital have ...