Fantasy Impact: ESPN’s Kris Rhim posits that the Chargers could be forced to lean on rookie running back Omarion Hampton in a way they “didn’t anticipate” in 2025. It would certainly make sense after Hampton erupted for 135 yards from scrimmage and a touchdown against the Broncos. Hampton vaults into the RB1 tier for the remainder of the season.

The Week 6 NFL lineup features top teams in action. Among those contests is the San Francisco 49ers taking on the Tampa Bay Buccaneers. With Week 6 in the NFL upon us, stay on top of the latest betting trends with our preview below.