Mitochondrial glutathione import via SLC25A39 supports breast cancer metastasis by linking glutathione availability to ATF4-driven integrated stress response signaling during early metastatic ...
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1Department of Biological Sciences, New York City College of Technology, City University of New York, Brooklyn, New York. 2Biology and Computer PhD Programs, The CUNY Graduate Center, City University ...
1Department of Obstetrics and Gynecology, Columbia University College of Physicians and Surgeons, New York, New York. 2Herbert Irving Comprehensive Cancer Center, New York, New York. 3New ...
Washington University School of Medicine in St. Louis, Saint Louis, MO.
1Division of Translational Radiation Sciences, Department of Radiation Oncology, University of Maryland School of Medicine, Baltimore, Maryland.
PARP inhibitor sensitivity is associated with cGAS–STING–IFN signaling, which can be harnessed by combining PARP inhibitors with STING agonists to overcome acquired resistance and requires NK cells to ...
Abstract. Molecular glue degrader (MGD) is an emerging therapeutic strategy offering an exciting alternative to traditional small molecules exploring new target space. These small molecules interact ...
The combination of anti-TROP2 ADCs with PD-(L)1 inhibitors represents a promising therapeutic strategy, merging targeted therapy with immunotherapy to improve treatment outcomes. Clinical trials are ...
Bristol Meyers Squib, Seattle, WA.
Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.
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